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Proceedings Paper

Optical fluorescence tomography with the equation of radiative transfer for molecular imaging
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Paper Abstract

Optical fluorescence tomography recovers the spatial distribution of light emitting fluorophores inside a highly scattering medium. The quantification of a non-uniform quantum yield and fluorophore absorption distribution is of major interest in molecular imaging of biological tissue. We have developed a fluorescence image reconstruction code that is based on the particle transport equation. Since the algorithm does not rely on the diffusion approximation it promises to yield more accurate results in highly absorbing media or media with small geometries. We show that the code can be employed in a two-stage reconstruction process to obtain images of the fluorophore absorption and of the quantum yield.

Paper Details

Date Published: 29 July 2003
PDF: 7 pages
Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); doi: 10.1117/12.478227
Show Author Affiliations
Alexander D. Klose, Columbia Univ. (United States)
Andreas H. Hielscher, Columbia Univ. (United States)

Published in SPIE Proceedings Vol. 4955:
Optical Tomography and Spectroscopy of Tissue V
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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