Share Email Print

Proceedings Paper

Breast lesion diagnosis using combined near-infrared diffusive light and ultrasound: initial clinical results
Author(s): Quing Zhu; Scott Kurtzman; Minming Huang; Nan Guang Chen; Kristen Zarfos; Bipin Jagjivan; Mark Kane
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Noninvasive diagnosis of solid benign and malignant tumors presents a unique challenge to all imaging modalidies. Ultrasound is routinely used in conjunction with mammography to deffierenciate simple cysts from solid lesions. However, the overlapping appearances of benign and malignant lesions make ultrasound less useful in differenciating solid lesions, which results in a large number of normal biopsies. Optical tomography using near infrared diffused light has a great potentional for imaging functional parameters of tumor total hemoglogin concentration, oxygeon saturation, and metabolism, etc, and these parameters can differenciate benign from malignant lesions. However, optical tomography alone suffers from low spatial resolution and target localization uncertainty due to the intensive light scattering inside the tissue. Our aims were to combine diffused light imaging with conventional ultrasound for detection and diagnosis of solid lesions. Initial findings of palpable and non-palpable solid breast lesions have shown that early stage invasive cancers have much higher total hemoglobin concentration due to angiogenesis than benign lesions. Furthermore, the spatial distribution of the total hemoglobin concentration is well localized in small invasive cancer cases, and is quite diffused in benign lesions.

Paper Details

Date Published: 29 July 2003
PDF: 14 pages
Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); doi: 10.1117/12.478220
Show Author Affiliations
Quing Zhu, Univ. of Connecticut (United States)
Scott Kurtzman, Univ. of Connecticut Health Ctr. (United States)
Minming Huang, Univ. of Connecticut (United States)
Nan Guang Chen, Univ. of Connecticut (United States)
Kristen Zarfos, Univ. of Connecticut Health Ctr. (United States)
Bipin Jagjivan, Univ. of Connecticut Health Ctr. (United States)
Mark Kane, Univ. of Connecticut Health Ctr. (United States)

Published in SPIE Proceedings Vol. 4955:
Optical Tomography and Spectroscopy of Tissue V
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

© SPIE. Terms of Use
Back to Top