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Proceedings Paper

Simulation of spectral reflectance of multiple scattering medium using the Mie theory combined with Monte Carlo method
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Paper Abstract

We present the method which can calculate the spectral reflectance from physical parameters corresponding to the pathological features, e.g. average size of cell nuclei and standard deviation of cell nuclear size distribution, in consideration of multiple scattering in biological tissue. In this paper, the method combined the Monte Carlo method which simulates multiple scattering effects and the Mie theory which provides phase function (angular properties of light scattering) and scattering coefficient was employed. In order to investigate the validity of this method, the calculated spectra by the method and Monte Carlo method with Henyey-Greenstein phase functions were compared with measurement spectra derived from the tissue phantom whose size distribution has double peaks. From the results, it is shown that the method can better predict the spectral reflectance of tissue phantom rather than Monte Carlo method with Henyey-Greenstein phase function.

Paper Details

Date Published: 29 July 2003
PDF: 9 pages
Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); doi: 10.1117/12.478215
Show Author Affiliations
Makoto Igarashi, Tokyo Institute of Technology (Japan)
Kazuhiro Gono, Tokyo Institute of Technology (Japan)
Takashi Obi, Tokyo Institute of Technology (Japan)
Masahiro Yamaguchi, Tokyo Institute of Technology (Japan)
Nagaaki Ohyama, Tokyo Institute of Technology (Japan)


Published in SPIE Proceedings Vol. 4955:
Optical Tomography and Spectroscopy of Tissue V
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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