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Proceedings Paper

Noninvasive cerebral hemoglobin oxygenation quantification of fetal sheep under hypoxic stress in utero using frequency-domain diffuse optical two-layer model
Author(s): Regine Choe; Turgut Durduran; Guoqiang Yu; Mark J. M. Nijland; Peter W. Nathanielsz; Britton Chance; Arjun G. Yodh; Nirmala Ramanujam
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Paper Abstract

A study using pregnant sheep was designed to simulate fetal hypoxia in order to investigate the ability of near-infrared spectroscopy (NIRS) to detect and quantify fetal hypoxia in utero. The near-infrared spectroscopic probe consisted of two detectors and six source positions. It was placed on the maternal ewe abdomen above the fetal head. The light sources were modulated at 70 MHz and frequency-encoded so that simultaneous measurements at 675, 786, 830 nm for each source position were possible. After the baseline measurements, fetal hypoxia was induced by blocking the aorta of pregnant ewe and thus compromising the blood supply to the uterus. Blood gas samples were concurrently drawn from the fetal brachial artery and jugular veins. Analysis of the diffuse optical data used a two-layer model to separate the maternal layer from the fetal head. The analysis also employed a priori spectral information about tissue chromophores. This approach provided good quantification of blood oxygenation changes, which correlated well with the blood gas analyses. By contrast the homogeneous model underestimated oxygenation changes during hypoxia.

Paper Details

Date Published: 29 July 2003
PDF: 9 pages
Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); doi: 10.1117/12.478175
Show Author Affiliations
Regine Choe, Univ. of Pennsylvania (United States)
Turgut Durduran, Univ. of Pennsylvania (United States)
Guoqiang Yu, Univ. of Pennsylvania (United States)
Mark J. M. Nijland, Cornell Univ. (United States)
Peter W. Nathanielsz, Cornell Univ. (United States)
Britton Chance, Univ. of Pennsylvania (United States)
Arjun G. Yodh, Univ. of Pennsylvania (United States)
Nirmala Ramanujam, Univ. of Wisconsin/Madison (United States)

Published in SPIE Proceedings Vol. 4955:
Optical Tomography and Spectroscopy of Tissue V
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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