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Proceedings Paper

Optical mammography with single-wavelength contrast enhancement and multiwavelength oxygenation assessment
Author(s): Sergio Fantini; Erica L. Heffer; Vivian E. Pera; Sylvia Heywang-Koebrunner; Linda Goetz; Anke Heinig; Oliver Schuetz; Horst Siebold
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Paper Abstract

We present a combination of (1) single-wavelength optical mammograms representing either the optical absorbance (N-images) or its spatial second-derivative (N’’-images), and (2) oxygenation-index images based on optical data at four wavelengths (690, 750, 788, and 856 nm). The enhanced contrast of the second-derivative images with respect to the absorbance images is complemented by the functional information provided by the oxygenation-index images. In a number of clinical cases, we have found that breast cancer is often associated with relatively low oxygenation indices, while benign breast lesions correspond to areas with relatively high oxygenation indices. However, the relative nature of the oxygenation-index presented in this work does not allow for a comparison of oxygenation values in different images, for which absolute oxygenation measurements would be needed.

Paper Details

Date Published: 29 July 2003
PDF: 8 pages
Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); doi: 10.1117/12.478129
Show Author Affiliations
Sergio Fantini, Tufts Univ. (United States)
Erica L. Heffer, Tufts Univ. (United States)
Vivian E. Pera, Tufts Univ. (United States)
Sylvia Heywang-Koebrunner, Martin-Luther-Univ. Halle-Wittenberg (Germany)
Linda Goetz, Martin Luther Univ. Halle-Wittenberg (Germany)
Anke Heinig, Martin Luther Univ. Halle-Wittenberg (Germany)
Oliver Schuetz, Siemens AG (Germany)
Horst Siebold, Siemens AG (Germany)

Published in SPIE Proceedings Vol. 4955:
Optical Tomography and Spectroscopy of Tissue V
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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