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Proceedings Paper

Detection of time window of cerebral blood flow response induced by sciatic nerve stimulation using temporal clustering analysis
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Paper Abstract

In many studies on functional neuroimaging, change in local cerebral blood flow (CBF) induced by sensory stimulation is used as a substitutive marker for change in cortical neuronal activity by Roy and Sherrington’s postulation. The purpose of this study is to evaluate the close temporal relationship between evoked local CBF and neuronal activity through utilizing temporal clustering analysis (TCA) method to analyze the dataset obtained by high-resolution laser speckle imaging (LSI). We mapped a relatively large somatosensory area of cerebral cortex in successively and followed variations of cerebral blood flow under sciatic nerve stimulation in anesthetized rats using LSI technique. Then we illustrated TCA method on the optical imaging signals and investigated the temporal characteristics of CBF activation. Contralateral somatosensory cortical microflow was activated to increase promptly in less than 1 second after the onset of 2 seconds electrical stimulation (pulse parameters: 0.5ms, 5Hz, 350mV). The data of the present study may possibly shed light on the development question of functional magnetic resonance imaging (fMRI) whether the ultimate spatial resolution attainable by fMRI is limited by the physiology of the cerebral blood flow response to activation or by the hardware and signal-to-noise ratio.

Paper Details

Date Published: 29 July 2003
PDF: 8 pages
Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); doi: 10.1117/12.478128
Show Author Affiliations
Zheng Wang, Huazhong Univ. of Science and Technology (China)
Qingming Luo, Huazhong Univ. of Science and Technology (China)
Haiying Cheng, Huazhong Univ. of Science and Technology (China)
Shaoqun Zeng, Huazhong Univ. of Science and Technology (China)

Published in SPIE Proceedings Vol. 4955:
Optical Tomography and Spectroscopy of Tissue V
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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