Share Email Print
cover

Proceedings Paper

Multimodal miniature microscope (4M Device): novel methodology for multimodality tissue imaging in vivo
Author(s): Junwon Lee; Jeremy D. Rogers; Dawn L. Nida; Jesse S. Aaron; Konstantin V. Sokolov; Rebecca R. Richards-Kortum; Michael R. Descour
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

We are developing a multi-modal miniature microscope (4M device) for imaging morphology and cytochemistry in vivo and providing better delineation of tumors. The 4M device is designed to be a complete microscope on a chip, including optical, micro-mechanical, and electronic components. It has advantages such as compact size and capability for microscopic-scale imaging. This paper presents the recent imaging experiment of 4M device including trans-illumination imaging, TIR illumination imaging and fluorescent imsging. We built a multi-modal imaging test-bed to demonstrate multi-modality of 4M device. In this paper, we present imaging experiment results by implementing various imaging modality with cervical cancer cells. In order to enhance image contrast, some imaging modality uses cells attached with contrast agency such as silver nano-particles. Imaging results indicate that the 4M prototype can resolve cellular detail necessary for detection of precancer.

Paper Details

Date Published: 19 June 2003
PDF: 9 pages
Proc. SPIE 4962, Manipulation and Analysis of Biomolecules, Cells, and Tissues, (19 June 2003); doi: 10.1117/12.478121
Show Author Affiliations
Junwon Lee, Optical Sciences Ctr./Univ. of Arizona (United States)
Jeremy D. Rogers, Optical Sciences Ctr./Univ. of Arizona (United States)
Dawn L. Nida, Univ. of Texas at Austin (United States)
Jesse S. Aaron, Univ. of Texas at Austin (United States)
Konstantin V. Sokolov, Univ. of Texas at Austin (United States)
Rebecca R. Richards-Kortum, Univ. of Texas at Austin (United States)
Michael R. Descour, Optical Sciences Ctr./Univ. of Arizona (United States)


Published in SPIE Proceedings Vol. 4962:
Manipulation and Analysis of Biomolecules, Cells, and Tissues
Dan V. Nicolau; Joerg Enderlein; Robert C. Leif; Daniel L. Farkas, Editor(s)

© SPIE. Terms of Use
Back to Top