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Proceedings Paper

Nonlinear matching measure for the analysis of on-off type DNA microarray images
Author(s): Jong Dae Kim; Misun Park; Jongwon Kim
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Paper Abstract

In this paper, we propose a new nonlinear matching measure for automatic analysis of the on-off type DNA microarray images in which the hybridized spots are detected by the template matching method. The targeting spots of HPV DNA chips are designed for genotyping the human papilloma virus(HPV). The proposed measure is obtained by binarythresholding over the whole template region and taking the number of white pixels inside the spotted area. This measure is evaluated in terms of the accuracy of the estimated marker location to show better performance than the normalized covariance.

Paper Details

Date Published: 18 July 2003
PDF: 10 pages
Proc. SPIE 4966, Microarrays and Combinatorial Technologies for Biomedical Applications: Design, Fabrication, and Analysis, (18 July 2003); doi: 10.1117/12.478054
Show Author Affiliations
Jong Dae Kim, Hallym Univ. (South Korea)
Misun Park, Biomedlab Co., Ltd. (United States)
Jongwon Kim, BioMedLab Co., Ltd. (South Korea)


Published in SPIE Proceedings Vol. 4966:
Microarrays and Combinatorial Technologies for Biomedical Applications: Design, Fabrication, and Analysis
Dan V. Nicolau; Ramesh Raghavachari, Editor(s)

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