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Proceedings Paper

In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography
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Paper Abstract

We present in vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer (RNFL) by use of polarization-sensitive optical coherence tomography (PS-OCT). Because glaucoma causes nerve fiber layer damage, which may cause loss of retinal birefringence, PS-OCT is a potentially useful technique for the early detection of glaucoma. We built a fiber-based PS-OCT setup that produces real-time images of the human retina in vivo, co-registered with video images of the location of PS-OCT scans on the retina. Preliminary measurements of a healthy volunteer showed that the double-pass phase retardation per unit depth of the RNFL varies with location with values in between 0.18 and 0.37°/μm. A trend in the preliminary measurements shows that thicker nerve fiber layer tissue is more birefringent than thin nerve fiber layer tissue.

Paper Details

Date Published: 14 July 2003
PDF: 5 pages
Proc. SPIE 4951, Ophthalmic Technologies XIII, (14 July 2003); doi: 10.1117/12.477971
Show Author Affiliations
Barry Cense, Harvard Medical School (United States)
Wellman Labs. of Photomedicine, Massachusetts General Hospital (United States)
Teresa C Chen, Massachusetts Eye and Ear Infirmary (United States)
Harvard Medical School (United States)
Boris Hyle Park, Harvard Medical School (United States)
Wellman Labs. of Photomedicine, Massachusetts General Hospital (United States)
Mark C. Pierce, Harvard Medical School (United States)
Wellman Labs. of Photomedicine, Massachusetts General Hospital (United States)
Johannes F. de Boer, Harvard Medical School (United States)
Wellman Labs. of Photomedicine, Massachusetts General Hospital (United States)


Published in SPIE Proceedings Vol. 4951:
Ophthalmic Technologies XIII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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