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Proceedings Paper

Spectral imaging of mouse skulls undergoing craniosynostosis
Author(s): Nicole J. Crane; Wei Wang; Michael A. Ignelzi; Michael D. Morris
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Paper Abstract

Craniosynostosis, the premature fusion of the skull bones at the sutures, is the second most common human birth defect that affects the face and skull. The top most flat bones that comprise the skull, or calvaria, are most often affected. We previously showed that treatment of mouse calvaria with FGF2-soaked beads leads to craniosynostosis. In this study we treated mouse calvaria with FGF2-soaked beads and then used Raman imaging to demonstrate the spatial distribution of apatitic mineral and matrix in the sutures. There was no difference between FGF2 treated and control calvaria in the type of mineral produced (a lightly carbonated apatite), however we did observe increased mineral deposition in FGF2 treated calvaria. Raman imaging has great promise to detect the earliest mineral and matrix changes that occur in craniosynostosis.

Paper Details

Date Published: 2 July 2003
PDF: 9 pages
Proc. SPIE 4959, Spectral Imaging: Instrumentation, Applications, and Analysis II, (2 July 2003); doi: 10.1117/12.477939
Show Author Affiliations
Nicole J. Crane, Univ. of Michigan (United States)
Wei Wang, Univ. of Michigan (United States)
Michael A. Ignelzi, Univ. of Michigan (United States)
Michael D. Morris, Univ. of Michigan (United States)


Published in SPIE Proceedings Vol. 4959:
Spectral Imaging: Instrumentation, Applications, and Analysis II
Richard M. Levenson; Gregory H. Bearman; Anita Mahadevan-Jansen, Editor(s)

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