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Proceedings Paper

Calculating the reduced scattering coefficient of turbid media from a single optical reflectance signal
Author(s): Maureen Johns; Hanli Liu
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Paper Abstract

When light interacts with tissue, it can be absorbed, scattered or reflected. Such quantitative information can be used to characterize the optical properties of tissue, differentiate tissue types in vivo, and identify normal versus diseased tissue. The purpose of this research is to develop an algorithm that determines the reduced scattering coefficient (μs’) of tissues from a single optical reflectance spectrum with a small source-detector separation. The basic relationship between μs’ and optical reflectance was developed using Monte Carlo simulations. This produced an analytical equation containing μs’ as a function of reflectance. To experimentally validate this relationship, a 1.3-mm diameter fiber optic probe containing two 400-micron diameter fibers was used to deliver light to and collect light from Intralipid solutions of various concentrations. Simultaneous measurements from optical reflectance and an ISS oximeter were performed to validate the calculated μs’ values determined by the reflectance measurement against the 'gold standard’ ISS readings. The calculated μs’ values deviate from the expected values by approximately ∓ 5% with Intralipid concentrations between 0.5 − 2.5%. The scattering properties within this concentration range are similar to those of in vivo tissues. Additional calculations are performed to determine the scattering properties of rat brain tissues and to discuss accuracy of the algorithm for measured samples with a broad range of the absorption coefficient (μa).

Paper Details

Date Published: 22 July 2003
PDF: 8 pages
Proc. SPIE 4958, Advanced Biomedical and Clinical Diagnostic Systems, (22 July 2003); doi: 10.1117/12.477937
Show Author Affiliations
Maureen Johns, Univ. of Texas at Arlington (United States)
Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Hanli Liu, Univ. of Texas at Arlington (United States)
Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)


Published in SPIE Proceedings Vol. 4958:
Advanced Biomedical and Clinical Diagnostic Systems
Tuan Vo-Dinh; Warren S. Grundfest; David A. Benaron; Gerald E. Cohn, Editor(s)

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