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Proceedings Paper

Development of a noninvasive corneal birefringence-compensated glucose-sensing polarimeter
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Paper Abstract

In the recent past, optical polarimetry has been shown as a potential method for noninvasive physiologic glucose sensing in the eye. Although the necessary sensitivity and accuracy have been demonstrated experimentally through in vitro studies using a range of media from simplistic glucose doped-water to more complex media such as aqueous humor, the main problem currently hindering long-term in vivo measurements is corneal birefringence coupled with motion artifact. This is due to the inability to distinguish E-field rotation due to glucose from the effects of time varying corneal birefringence. In this investigation, the effect of corneal birefringence will be discussed and a potential method to overcome this problem will be presented with supporting results.

Paper Details

Date Published: 22 July 2003
PDF: 10 pages
Proc. SPIE 4958, Advanced Biomedical and Clinical Diagnostic Systems, (22 July 2003); doi: 10.1117/12.477864
Show Author Affiliations
Harini Anumula, Univ. of Toledo (United States)
Ajaina A. Nezhuvingal, Univ. of Toledo (United States)
Yanfang Li, Univ. of Toledo (United States)
Brent D. Cameron, Univ. of Toledo (United States)


Published in SPIE Proceedings Vol. 4958:
Advanced Biomedical and Clinical Diagnostic Systems
Tuan Vo-Dinh; Warren S. Grundfest; David A. Benaron; Gerald E. Cohn, Editor(s)

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