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Proceedings Paper

Optical modeling of cylindrical light sources within tissue
Author(s): Zihong Guo; Steven R. Daly; Jennifer K. Matson
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Paper Abstract

The objective of this study was to model the optical profile of a proprietary light source in various simulated biological tissues using Monte Carlo based raytracing software. The proprietary light source, built by Light Sciences Corporation, has an LED array at its distal end and is being evaluated for use as an intratumoral PDT treatment device. The light source was scanned in a goniometer to characterize its optical geometry in air and this data provided the basis for an optical model of the device. The bulk scattering effect of the model in biological tissue was then simulated using the raytracing software. The simulated results were further verified with experimental measurements in phantom medium. The simulated results indicated a non-uniform light distribution along the LED array axis in air. In addition, the light distribution at cross section normal to the LED array axis is "butterfly" in shape with the differences of the peak to average approximately ±42%. However, the optical profile of the light source in a bulk scattering tissue became much more uniform than those in air, with a peak to average spread in cross section of ±15%.

Paper Details

Date Published: 27 August 2003
PDF: 8 pages
Proc. SPIE 4961, Laser-Tissue Interaction XIV, (27 August 2003); doi: 10.1117/12.477708
Show Author Affiliations
Zihong Guo, Light Sciences Corp. (United States)
Steven R. Daly, Light Sciences Corp. (United States)
Jennifer K. Matson, Light Sciences Corp. (United States)

Published in SPIE Proceedings Vol. 4961:
Laser-Tissue Interaction XIV
Donald Dean Duncan; Sean J. Kirkpatrick; Andres Kriete; Steven L. Jacques, Editor(s)

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