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Proceedings Paper

Optical images from pathophysiological signals within breast tissue using three-dimensional near-infrared light
Author(s): Hamid Dehghani; Brian W. Pogue; Shudong Jiang; Steven P. Poplack; Keith D. Paulsen
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Paper Abstract

Near Infrared (NIR) tomography has the potential for characterization of different tissue types based upon cellular and vascular alternations that are optically apparent. This is especially useful for characterizing cancerous regions within normal tissue due to the high available contrast. Reconstructed images from NIR light propagation measurements through the female breast hold promise of providing clinically useful information about the pathophysiologic change of the tissue. We have developed a fast three-dimensional finite element model and image reconstruction algorithm, NIRFAST (Near Infrared Frequency-Domain Absorption and Scatter Tomography) and have previously tested the results extensively against simulated and phantom data. The results have shown that the reconstructed images have good accuracy in recovering optical changes within the medium under investigation, and that with appropriate constraints, the calculated quantitative values agree well with the true values. Based on these algorithms, we present true three-dimensional images of the breast, from patient data. These images, which are reconstructed using NIR measurements over a range of wavelengths, provide additional information regarding the blood content and oxygen saturation distribution within the breast.

Paper Details

Date Published: 29 July 2003
PDF: 8 pages
Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); doi: 10.1117/12.476807
Show Author Affiliations
Hamid Dehghani, Dartmouth College (United States)
Dartmouth-Hitchcock Medical Ctr. (United States)
Brian W. Pogue, Dartmouth College (United States)
Shudong Jiang, Dartmouth College (United States)
Steven P. Poplack, Dartmouth-Hitchcock Medical Ctr. (United States)
Keith D. Paulsen, Dartmouth College (United States)

Published in SPIE Proceedings Vol. 4955:
Optical Tomography and Spectroscopy of Tissue V
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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