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Proceedings Paper

High-temperature thermal treatment of the uterus
Author(s): Thomas P. Ryan; Jia Hua Xiao; Juh Yun Chung
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Paper Abstract

More than 200,000 hysterectomies are performed annually in the US due to abnormal uterine bleeding from excessive menstrual flow. A minimally invasive procedure has been developed using thermal treatment combined with pressure to the endometrial lining of the uterus. Results from a 3-D finite element model will be shown, as well as experimental data. Good correlation was seen between simulations and experiments. The study found similar results then temperatures were increased and times for treatment were shortened.More than 200,000 hysterectomies are performed annually in the US due to abnormal uterine bleeding from excessive menstrual flow. A minimally invasive procedure has been developed using a balloon-based thermal treatment combined with pressure to the endometrial lining of the uterus. A 3D finite element model was set up to simulate the balloon ablation device in the human uterus as used in over 150,000 patients to date. Several additional simulations were made at higher temperatures to seek alternative combinations with higher temperature and shorter time intervals for the same depth of penetration, or deeper penetration at longer times and elevated temperatures. A temperature range of 87 to 150°C was explored. The Bioheat Equation was used in the simulations to predict temperature distributions in tissue. The Damage Integral was also used to characterize the location at depth of irreversible damage in the uterus. Treatment safety issues were also analyzed as the simulations showed the depth of penetration into the myometrium, towards the serosa.

Paper Details

Date Published: 10 June 2003
PDF: 14 pages
Proc. SPIE 4954, Thermal Treatment of Tissue: Energy Delivery and Assessment II, (10 June 2003); doi: 10.1117/12.476629
Show Author Affiliations
Thomas P. Ryan, Ethicon Inc. (United States)
Jia Hua Xiao, Ethicon Inc. (United States)
Juh Yun Chung, Rutgers University (United States)


Published in SPIE Proceedings Vol. 4954:
Thermal Treatment of Tissue: Energy Delivery and Assessment II
Thomas P. Ryan, Editor(s)

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