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Proceedings Paper

MR-guided conformal heating of canine prostate using interstitial applicators
Author(s): William H. Nau; Chris J. Diederich; Anthony Ross; R. Kim Butts; Viola Rieke; Donna Bouley; Harchi Gill; Bruce Daniel; Graham Sommer
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Paper Abstract

MRI compatible, multi-element ultrasound applicators were fabricated using cylindrical piezoceramic transducers sectored to 180 degrees to provide angular directional heating. The applicators were designed to be inserted into standard 13 or 14 gage brachytherapy catheters integrated with water-cooling. Two applicators were inserted transperinealy into the posterior region of a canine prostate. Power output ranged from 5-15 W per element during the 15 minute heating period. Phase-sensitive gradient-recalled MR imaging was used to monitor the treatment in real-time on a 0.5 Tesla MRT system. Gadolinium-enhanced T1 weighted images and diffusion-weighted images were obtained to view the regions which had been ablated during the heating procedure. Upon euthanasia, the prostate was removed, axially sectioned, and stained with TTC to reveal any regions of remaining viable tissue. Results from this study indicated a large volume of ablated tissue within the prostate which was highly correlated to the regions in the T1-weighted and diffusion-weighted images which had decreased intensity, and to the 52C contour displayed in the images obtained during the treatment. This study demonstrates the ability to control thermal coagulation within a targeted tissue volume while protecting surrounding tissue from thermal damage.

Paper Details

Date Published: 10 June 2003
PDF: 7 pages
Proc. SPIE 4954, Thermal Treatment of Tissue: Energy Delivery and Assessment II, (10 June 2003); doi: 10.1117/12.476608
Show Author Affiliations
William H. Nau, Univ. of California/San Francisco (United States)
Chris J. Diederich, Univ. of California/San Francisco (United States)
Anthony Ross, Univ. of California/San Francisco (United States)
R. Kim Butts, Stanford Univ. (United States)
Viola Rieke, Stanford Univ. (United States)
Donna Bouley, Stanford Univ. (United States)
Harchi Gill, Stanford Univ. (United States)
Bruce Daniel, Stanford Univ. (United States)
Graham Sommer, Stanford Univ. (United States)

Published in SPIE Proceedings Vol. 4954:
Thermal Treatment of Tissue: Energy Delivery and Assessment II
Thomas P. Ryan, Editor(s)

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