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Proceedings Paper

In vivo local determination of tissue optical properties: instrumentation and application
Author(s): Wei Zhang; Hui Gong; Guiling Wu; Pengcheng Li; Qingming Luo
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Paper Abstract

We have developed an optical probe for local determination of tissue optical properties using a small source-detector separation (<1mm). A 1310nm LED (25 μW) coupled to a fiber with 62.5 μm diameter was used as the light source and multiple detector fibers were employed to achieve spatially resolved reflectance measurement. Each detector fiber has a diameter of 62.5 μm and apart away 125 μm from each other. Pin detectors and continuous wave detection scheme were performed to obtain a sensitivity of 4x109V/W and 82dB dynamic range. Applied to the normal human skin in the forearm, 63dB signal to noise ration can be achieved with a time resolution less than 1 second. The absorption and scattering coefficientions of tissue can be calculated by generalized diffusion approximation with measured reflective intensity. In this paper, we discussed the design of the system in general, and then described our instrument, along with the technique issues that influenced its design. Phantom experimental was performed to analyze the relationship between the reflectance light and the optical properties (μa, μs). The results showed that this optical probe could be used for local determination of tissue optical properties.

Paper Details

Date Published: 22 July 2003
PDF: 7 pages
Proc. SPIE 4958, Advanced Biomedical and Clinical Diagnostic Systems, (22 July 2003); doi: 10.1117/12.476138
Show Author Affiliations
Wei Zhang, Huazhong Univ. of Science and Technology (China)
Hui Gong, Huazhong Univ. of Science and Technology (China)
Guiling Wu, Huazhong Univ. of Science and Technology (China)
Pengcheng Li, Huazhong Univ. of Science and Technology (China)
Qingming Luo, Huazhong Univ. of Science and Technology (China)


Published in SPIE Proceedings Vol. 4958:
Advanced Biomedical and Clinical Diagnostic Systems
Tuan Vo-Dinh; Warren S. Grundfest; David A. Benaron; Gerald E. Cohn, Editor(s)

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