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Proceedings Paper

Thermal response of human skin epidermis in different skin types to 595-nm laser irradiation and cryogen spray cooling: an ex-vivo study
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Paper Abstract

Improved laser treatment of port wine stains is expected by utilizing higher incident dosages, longer pulse durations, and longer wavelengths than those currently used in clinical settings. However, higher incident dosages also increase the risk of nonspecific thermal injury to the epidermis. Using ex-vivo human skin samples, we investigated the thermal respone of human skin epidermis in different skin types ot 595-nm wavelength laser irradiation at high incident dosages (up to 20 J/cm2) and long pulse durations (1.5 to 40 milliseconds) in conjunction with cryogen spray cooling (CSC). Human skin samples (Fitzpatrick types I-VI) from consenting adult females undergoing trans-rectus abdominis myocutaneoues flap procedures were irradiated at the incident dosages D0=4, 6, 10, 15, and 20 J/cm2, pulse durations τlaser=1.5, 10, and 40 milliseconds without and with CSC (Refrigerant-134A, spurt duration τCSC=100 milliseconds). Thermal injury to the epidermis was evaluated by histological observations. Experimental results showed that thermal injury to the epidermis could not be avoided in skin type VI even at D0 = 4 J/cm2 in conjunction with CSC. However, CSC allowed utilization of high incident dosages (15 - 20 J/cm2) in skin types I-IV. Under the same incident dosage, longer pulse durations led to decreased degree of thermal injury to the epidermis. Threshold values for irradiation parameters that resulted in thermal injury to the epidermis for each skin type were obtained.

Paper Details

Date Published: 12 September 2003
PDF: 9 pages
Proc. SPIE 4949, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIII, (12 September 2003); doi: 10.1117/12.476134
Show Author Affiliations
Tianhong Dai, Rice Univ. (United States)
Brian M. Pikkula, Rice Univ. (United States)
James William Tunnell, Rice Univ. (United States)
David Chang, M.D. Anderson Cancer Ctr., Univ. of Texas (United States)
Bahman Anvari, Rice Univ. (United States)


Published in SPIE Proceedings Vol. 4949:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIII
Eugene A. Trowers; Timothy A. Woodward; Werner T.W. de Riese; Lawrence S. Bass; Nikiforos Kollias; Udayan K. Shah; Brian Jet-Fei Wong; Reza S. Malek; David S. Robinson; Hans-Dieter Reidenbach; Keith D. Paulsen; Kenton W. Gregory; Lawrence S. Bass; Abraham Katzir, Editor(s)

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