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Proceedings Paper

Implementation of near-infrared spectroscopy in a rat model of cardiac arrest and resuscitation
Author(s): Juan G. Rodriguez; Feng Xiao; Davon Ferrara; Jennifer Ewing; Shu Zhang; Steven Alexander; Harold Battarbee
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Paper Abstract

Transient global cerebral ischemia accompanying cardiac arrest (CA) often leads to permanent brain damage with poor neurological outcome. The precise chain of events underlying the cerebral damage after CA is still not fully understood. Progress in this area may profit from the development of new non-invasive tools that provide real-time information on the vascular and cellular processes preceding the damage. One way to assess these processes is through near-IR spectroscopy, which has demonstrated the ability to quantify changes in blood volume, hemoglobin oxygenation, cytochrome oxidase redox state, and tissue water content. Here we report on the successful implementation of this form of spectroscopy in a rat model of asphyxial CA and resuscitation, under hypothermic and normothermic conditions. Preliminary results are shown that provide a new temporal insight into the cerebral circulation during CA and post-resuscitation.

Paper Details

Date Published: 16 July 2002
PDF: 9 pages
Proc. SPIE 4707, Saratov Fall Meeting 2001: Optical Technologies in Biophysics and Medicine III, (16 July 2002); doi: 10.1117/12.475638
Show Author Affiliations
Juan G. Rodriguez, Louisiana State Univ. Health Sciences Ctr. and Centenary College of Louisiana (United States)
Feng Xiao, Louisiana State Univ. Health Sciences Ctr. (United States)
Davon Ferrara, Centenary College of Louisiana (United States)
Jennifer Ewing, Centenary College of Louisiana (United States)
Shu Zhang, Louisiana State Univ. Health Sciences Ctr. (United States)
Steven Alexander, Louisiana State Univ. Health Sciences Ctr. (United States)
Harold Battarbee, Louisiana State Univ. Health Sciences Ctr. (United States)


Published in SPIE Proceedings Vol. 4707:
Saratov Fall Meeting 2001: Optical Technologies in Biophysics and Medicine III

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