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Proceedings Paper

Mathematical model of cAMP-dependent signaling pathway in constitutive and UV-induced melanogenesis
Author(s): Mikhail M. Stolnitz; Anna Yu. Peshkova
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Paper Abstract

Cascade of reactions of cAMP-dependent signaling pathway in melanocytes is investigated by mathematical modeling. Model takes into account (alpha) -melanocyte stimulating hormone binding to melanocortin-1 receptor, adenylate cyclase activation by G-protein, increase of the intracellular cAMP concentration, PKA activation by cAMP, CREB phosphorylation by PKA, microphthalmia gene expression, microphthalmia binding to tyrosinase gene promoter, increase of tyrosinase synthesis. Positive and negative feedback loops of this system are analyzed.

Paper Details

Date Published: 16 July 2002
PDF: 9 pages
Proc. SPIE 4707, Saratov Fall Meeting 2001: Optical Technologies in Biophysics and Medicine III, (16 July 2002); doi: 10.1117/12.475600
Show Author Affiliations
Mikhail M. Stolnitz, Saratov State Univ. (Russia)
Anna Yu. Peshkova, Saratov State Univ. (Russia)


Published in SPIE Proceedings Vol. 4707:
Saratov Fall Meeting 2001: Optical Technologies in Biophysics and Medicine III

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