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Proceedings Paper

Optical methods for the analysis of dermatopharmacokinetics
Author(s): Juergen Lademann; Hans-Juergen Weigmann; R. von Pelchrzim; Wolfram Sterry
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Paper Abstract

The method of tape stripping in combination with spectroscopic measurements is a simple and noninvasive method for the analysis of dermatopharmacokinetics of cosmetic products and topically applied drugs. The absorbance at 430 nm was used for the characterization of the amount of corneocytes on the tape strips. It was compared to the increase of weight of the tapes after removing them from the skin surface. The penetration profiles of two UV filter substances used in sunscreens were determined. The combined method of tape stripping and spectroscopic measurements can be also used for the investigation of the dermatopharmacokinetics of topically applied drugs passing through the skin. Differences in the penetration profiles of the steroid compound clobetasol, applied in the same concentration in different formulations on the skin are presented.

Paper Details

Date Published: 16 July 2002
PDF: 8 pages
Proc. SPIE 4707, Saratov Fall Meeting 2001: Optical Technologies in Biophysics and Medicine III, (16 July 2002); doi: 10.1117/12.475577
Show Author Affiliations
Juergen Lademann, Dermatological Clinic of the Charite Berlin (Germany)
Hans-Juergen Weigmann, Dermatological Clinic of the Charite Berlin (Germany)
R. von Pelchrzim, Dermatological Clinic of the Charite Berlin (Germany)
Wolfram Sterry, Dermatological Clinic of the Charite Berlin (Germany)


Published in SPIE Proceedings Vol. 4707:
Saratov Fall Meeting 2001: Optical Technologies in Biophysics and Medicine III

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