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Proceedings Paper

Optical anomalies in biological media: using naturally occurring birefringence and radiance-dependent nonlinear optics to our advantage in the laser treatment of arrhythmias
Author(s): Robert Splinter; Robert H. Svenson; Eduardo Sosa; Andre Luiz Buchele d'Avila; Mauricio Scanavacca; Ernest Pruitt; Jackie H. Kasell
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Paper Abstract

When irradiating particular biological media in general there will be a range of optical properties to deal with, with respect to the irradiating wavelength, and the respective tissues that make up the organ under treatment or being imaged. In addition to this we saw changing optical properties under influence of denaturization, dehydration and carbonization. We also observed optical nonlinearities that are irradiance dependent, in addition to the birefringence which affects the light distribution throughout the tissue differently than the polarization birefringence used in optical polarization microscopy. In the treatment of ventricular tachycardia with laser photocoagulation the success of the procedure depends on whether sufficient energy has been directed to the relevant region of the myocardium to ablate the entire arrhythmogenic focus. A new high power diode laser operating in the near infrared was used in an animal infarct model and in human arrhythmia ablation. The light distribution measured for Chagasic heart tissues at the diode laser wavelength demonstrated the key potential to create controlled deep photocoagulation lesions. From our observations we may conclude that the diode laser - catheter combination offers significant potential for the elimination of arrhythmia's resulting from Chagas disease.

Paper Details

Date Published: 17 February 2003
PDF: 9 pages
Proc. SPIE 4833, Applications of Photonic Technology 5, (17 February 2003); doi: 10.1117/12.474301
Show Author Affiliations
Robert Splinter, Carolinas Medical Ctr. (United States)
Robert H. Svenson, Sanger Clinic (United States)
Eduardo Sosa, Instituto de Coracao (Brazil)
Andre Luiz Buchele d'Avila, Instituto do Coracao (Brazil)
Mauricio Scanavacca, Instituto do Coracao (Brazil)
Ernest Pruitt, Lightwave Ablation Systems, Inc. (United States)
Jackie H. Kasell, Lightwave Ablation Systems, Inc. (United States)

Published in SPIE Proceedings Vol. 4833:
Applications of Photonic Technology 5
Roger A. Lessard; George A. Lampropoulos; Gregory W. Schinn, Editor(s)

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