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Proceedings Paper

Effect of photodynamic therapy with verteporfin on tumor blood flow
Author(s): Bin Chen; Brian W. Pogue; Isak A. Goodwin; Julia A. O'Hara; Carmen M. Wilmot; John E. Hutchins; P. Jack Hoopes; Tayyaba Hasan
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Paper Abstract

The success of photodynamic therapy with verteporfin is partially determined by the pharmacokinetic distribution of the sensitizer at the time of treatment. In this study tumor blood flow changes in the RIF-1 murine tumor model and tumor resopnse using the regrowth assay were measured, comparing two different intervals between drug and light administration. Blood flow measurements were taken with a laser Doppler system monitoring continuously over 1 hour and periodically up to 6 hours after treatment. Treatment after the longer interval caused significantly less flow decrease, to only 50% of the initial flow in 6 h. Hoechst staining of functional tumor vasculature confirmed the primary vascular damage and the decrease in tumor perfusion. The regrowth rate of tumors after the longer time interval, the regrowth rate was not signifincalty different from that of the control, indicating that only the 15-min interval group caused serious damage to the vascular bed of the tumor. These studies support the hypothesis that temporal pharmacokinetic changes in the photosensitizer distribution between the tumor parenchyma and blood vessels can significantly alter the mechanism of tumor targeting during therapy.

Paper Details

Date Published: 13 June 2003
PDF: 8 pages
Proc. SPIE 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII, (13 June 2003); doi: 10.1117/12.474082
Show Author Affiliations
Bin Chen, Dartmouth College (United States)
Brian W. Pogue, Dartmouth College (United States)
Wellman Labs. of Photomedicine/Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Isak A. Goodwin, Dartmouth College (United States)
Julia A. O'Hara, Dartmouth Medical School (United States)
Carmen M. Wilmot, Wellman Labs. of Photomedicine/Massachusetts General Hospital (United States)
Harvard Medical School (United States)
John E. Hutchins, Dartmouth Medical School (United States)
P. Jack Hoopes, Dartmouth College (United States)
Dartmouth Medical School (United States)
Tayyaba Hasan, Massachusetts General Hospital (United States)
Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 4952:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII
David Kessel, Editor(s)

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