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Proceedings Paper

Selective damage of pigmented cells by means of a rapidly scanned cw laser beam
Author(s): Ralf Brinkmann; Norbert Koop; Mustafa Oezdemir; Clemens Alt; Georg Schuele; Charles P. Lin; Reginald Birngruber
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Paper Abstract

Selective targeting the retinal pigment epithelium (RPE) while sparing adjacent tissue such as the photoreceptors has been demonstrated by repetitively irradiating the fundus with a train of green microsecond(s) -laser pulses. The aim of this study was to investigate selective RPE effects alternatively by means of rapidly scanning a cw-laser beam across the RPE to obtain the required microsecond(s) -illumination times. The radiation of an Ar+ laser (514 nm) was transmitted through a 25-micrometers core diameter fiber to a scanner unit. The fiber tip was imaged onto the object plane with a magnification of 0.75. The beam was repetitively scanned across porcine RPE samples in vitro providing an irradiation time of 1.6 microsecond(s) . Cell damage was investigated with a fluorescence viability assay.

Paper Details

Date Published: 27 June 2002
PDF: 7 pages
Proc. SPIE 4617, Laser Tissue Interaction XIII: Photochemical, Photothermal, and Photomechanical, (27 June 2002); doi: 10.1117/12.472538
Show Author Affiliations
Ralf Brinkmann, Medical Laser Ctr. Luebeck (Germany)
Norbert Koop, Medical Laser Ctr. Luebeck (Germany)
Mustafa Oezdemir, Medical Laser Ctr. Luebeck (Germany)
Clemens Alt, Medical Laser Ctr. Luebeck (United States)
Georg Schuele, Medical Laser Ctr. Luebeck (Germany)
Charles P. Lin, Harvard Medical School (United States)
Reginald Birngruber, Medical Laser Ctr. Luebeck (Germany)

Published in SPIE Proceedings Vol. 4617:
Laser Tissue Interaction XIII: Photochemical, Photothermal, and Photomechanical
Steven L. Jacques; Donald Dean Duncan; Donald Dean Duncan; Sean J. Kirkpatrick; Sean J. Kirkpatrick; Andres Kriete; Andres Kriete, Editor(s)

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