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Proceedings Paper

Selective photothermal interaction using near-infrared laser and laser-absorbing dye in gel phantom and chicken breast tissue
Author(s): Thomas M. Cowan; Guangyu Liu; Sarah Simmons; Jeremy Real; Michael D. Lucroy; Kenneth Eugene Bartels; Robert E. Nordquist; Wei R. Chen
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Paper Abstract

Photothermal interaction of an 805-nm diode laser with an absorptive dye, indocyanine green (ICG), has been shown to be an efficacious therapy for metastatic breast tumors in a rat model when combined with immunoadjuvant. When ICG solution was injected into the target tissue, selective tissue destruction can be achieved. To study the selective photothermal interaction, temperature change in irradiated tissue was achieved. To study the selective photothermal interaction, temperature change in irradiated tissue was studied using chicken breast tissue and phantom composed of gelatin and intralipid. ICG solution was mixed with gel phantom to simulate dye-enhanced target tissue. The target gel was then embedded in chicken breast tissue. The temperature change of irradiated chicken and gel phantom was measured by needle temperature probes at different tissue depths and radii from the center of the laser beam to construct a two-dimensional array of temperature change in a cylindrical coordinate system. It was shown that it is possible to selectively raise the temperature of deep target tissue while not substantially heating nontargeted tissue. A Nd:YAG laser was also used to irradiate the tissue-gel system and the photothermal results were compared with that using the 805-nm laser.

Paper Details

Date Published: 27 June 2002
PDF: 8 pages
Proc. SPIE 4617, Laser Tissue Interaction XIII: Photochemical, Photothermal, and Photomechanical, (27 June 2002); doi: 10.1117/12.472528
Show Author Affiliations
Thomas M. Cowan, Univ. of Central Oklahoma (United States)
Guangyu Liu, Univ. of Central Oklahoma (United States)
Sarah Simmons, Univ. of Central Oklahoma (United States)
Jeremy Real, Univ. of Central Oklahoma (United States)
Michael D. Lucroy, Oklahoma State Univ. College of Veterinary Medicine and Ctr. for Laser Research (United States)
Kenneth Eugene Bartels, Oklahoma State Univ. College of Veterinary Medicine and Ctr. for Laser Research (United States)
Robert E. Nordquist, Wound Healing of Oklahoma, Inc. (United States)
Wei R. Chen, Univ. of Central Oklahoma and Univ. of Oklahoma (United States)


Published in SPIE Proceedings Vol. 4617:
Laser Tissue Interaction XIII: Photochemical, Photothermal, and Photomechanical
Steven L. Jacques; Donald Dean Duncan; Sean J. Kirkpatrick; Andres Kriete; Donald Dean Duncan; Sean J. Kirkpatrick; Andres Kriete, Editor(s)

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