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Proceedings Paper

Cytotoxicity in cultured RPE: a comparative study between continuous-wave and mode-locked lasers
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Paper Abstract

We have previously shown that minimum visible lesions (MVL) generated in vivo by exposures at threshold energies are not ophthalmoscopically visible at one hour, but become visible 24 hours post-exposure. Our preliminary studies toward understanding this phenomenon at the molecular level are presented. We provide threshold data relating cytotoxicity with energy for acute laser exposures in cultured retinal pigment epithelial cells. Rapid loss of cell viability is used as an initial endpoint of analysis. Comparisons of damage efficiency for continuous wave and mode-locked lasers are presented.

Paper Details

Date Published: 27 June 2002
PDF: 5 pages
Proc. SPIE 4617, Laser Tissue Interaction XIII: Photochemical, Photothermal, and Photomechanical, (27 June 2002); doi: 10.1117/12.472519
Show Author Affiliations
Michael L. Denton, Northrop Grumman Corp. (United States)
Debbie M. Eikum, Northrop Grumman Corp. (United States)
David J. Stolarski, Northrop Grumman Corp. (United States)
Gary D. Noojin, Northrop Grumman Corp. (United States)
Robert J. Thomas, Northrop Grumman Corp. (United States)
Randolph D. Glickman, Univ. of Texas Health Science Ctr./San Antonio (United States)
Benjamin A. Rockwell, Air Force Research Lab. (United States)

Published in SPIE Proceedings Vol. 4617:
Laser Tissue Interaction XIII: Photochemical, Photothermal, and Photomechanical
Steven L. Jacques; Donald Dean Duncan; Donald Dean Duncan; Sean J. Kirkpatrick; Sean J. Kirkpatrick; Andres Kriete; Andres Kriete, Editor(s)

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