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Proceedings Paper

Model of protein adsorption to solid surfaces from solution
Author(s): Dan V. Nicolau
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Paper Abstract

The absorption of biomolecules on surfaces is a perennial and general problem relevant to fields as different as biomaterials, biosensors, microarrays for proteomics and microfluidics. The 'responsiveness-to-surfaces' character of the proteins augments the difficulty of the general problem of biomolecule adsorption on surfaces. This complexity of protein adsorption generated a large number of contributions over the years, with a rate not showing signs of slowing down. This contribution proposes the use of existent data, as well as data generated in 'programmatic', factorial experiments, to generate scaling relationships regarding protein attachment on polymer surfaces linking protein molecular descriptors, surface descriptors and solution descriptors in a common, quasi-empirical 'engineering' relationships. These relationships can be used for the design of surfaces for proteomics microarrays and microfluidic devices.

Paper Details

Date Published: 21 June 2002
PDF: 8 pages
Proc. SPIE 4626, Biomedical Nanotechnology Architectures and Applications, (21 June 2002); doi: 10.1117/12.472083
Show Author Affiliations
Dan V. Nicolau, Univ. of Melbourne (Australia)

Published in SPIE Proceedings Vol. 4626:
Biomedical Nanotechnology Architectures and Applications
Raymond P. Mariella; Catherine J. Murphy; Michelle Palmer; David A. Dunn; Darryl J. Bornhop; David A. Dunn; Raymond P. Mariella; Catherine J. Murphy; Dan V. Nicolau; Shuming Nie; Michelle Palmer; Ramesh Raghavachari; Darryl J. Bornhop; Ramesh Raghavachari; Shuming Nie; Ramesh Raghavachari, Editor(s)

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