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Proceedings Paper

Pd tetrabenzoporphyrin-dendrimers: near-infrared phosphors for oxygen measurements by phosphorescence quenching
Author(s): Sergei A. Vinogradov; Evelyn Kim; David F. Wilson
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Paper Abstract

Phosphorescence quenching is an optical method for measuring tissue oxygenation. The technique is based on the quenching of phosphorescence originated from the injected dye by molecule oxygen dissolved in the medium. The phosphor is the only 'invasive' component of the measurement procedure, and thus it is important to have precise control over the bio- distribution of the phosphor, i.e. to confine it to a single compartment within the sample. For tissue applications the phosphor must also be an effective light absorber in the near IR and to exhibit oxygen quenching constant of 200-400 Torr-1 sec-1, to permit reliable quantification of oxygen in arterioles as well as in veins. Overall, it is desirable to have synthetic, inert, hydrophilic, phosphors with quenching characteristics that are not affected by molecules other than oxygen. We discuss a new generation of phosphors based on dendrimer- tetrabenzoporphyrins, designed to satisfy the above criteria. In these phosphors, the core metallotetrabenzoporphyrins prove the required physical characteristics, while their immediate surrounding environments consist of covalently attached dendritic branches. The dendritic cages around porphyrins control their quenching properties and protect porphyrins from interactions with other substances in the blood.

Paper Details

Date Published: 21 June 2002
PDF: 8 pages
Proc. SPIE 4626, Biomedical Nanotechnology Architectures and Applications, (21 June 2002); doi: 10.1117/12.472081
Show Author Affiliations
Sergei A. Vinogradov, Univ. of Pennsylvania (United States)
Evelyn Kim, Univ. of Pennsylvania (United States)
David F. Wilson, Univ. of Pennsylvania (United States)

Published in SPIE Proceedings Vol. 4626:
Biomedical Nanotechnology Architectures and Applications
Raymond P. Mariella; Michelle Palmer; Darryl J. Bornhop; Darryl J. Bornhop; Ramesh Raghavachari; Shuming Nie; Ramesh Raghavachari; Catherine J. Murphy; David A. Dunn; David A. Dunn; Raymond P. Mariella; Catherine J. Murphy; Dan V. Nicolau; Shuming Nie; Michelle Palmer; Ramesh Raghavachari, Editor(s)

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