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Proceedings Paper

Database comprising biomolecular descriptors relevant to protein adsorption on microarray surfaces
Author(s): Dan V. Nicolau
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Paper Abstract

The adsorption of biomolecules on surfaces is dependent on biomolecule molecular descriptors, surface descriptors and environment descriptors. Of these descriptors, the biomolecular-related are the most complex and arguably the most important, as being related to both adsorption and possible denaturation on surfaces. The criticality of biomolecule adsorption in the context of microarrays and microfluidics devices will increase with the advancement of proteomics that probes the functionality of proteins, which are much more responsive to surfaces than DNA - the focal biomolecule of genomics. Anticipating this development, the present contribution proposes the establishment of a biomolecular descriptors database, which could be the starting point for a depositary of data and a source of validation for predictive models for adsorption and denaturation.

Paper Details

Date Published: 21 June 2002
PDF: 7 pages
Proc. SPIE 4626, Biomedical Nanotechnology Architectures and Applications, (21 June 2002); doi: 10.1117/12.472070
Show Author Affiliations
Dan V. Nicolau, Univ. of Melbourne (Australia)

Published in SPIE Proceedings Vol. 4626:
Biomedical Nanotechnology Architectures and Applications
Raymond P. Mariella; Michelle Palmer; Darryl J. Bornhop; Darryl J. Bornhop; Ramesh Raghavachari; Shuming Nie; Ramesh Raghavachari; Catherine J. Murphy; David A. Dunn; David A. Dunn; Raymond P. Mariella; Catherine J. Murphy; Dan V. Nicolau; Shuming Nie; Michelle Palmer; Ramesh Raghavachari, Editor(s)

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