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Proceedings Paper

Physico-chemical features of PDMS for use in microchip development for genetic testing
Author(s): Boris G. Belenkii; Oleg F. Pozdnyakov; Anatolii A. Evstrapov; Victor V. Filimonov; Vladimir E. Kurochkin; Boris P. Redkov; Vladislav L. Sukhanov; Zinaida V. Nesterova
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Paper Abstract

Previous attempts have been made to integrate gene amplification (PCR) with electrophoretic separation of PCR products on a chip fabricated in PDMS. PDMS is a widely used elastic polymer for rapid prototyping using soft lithography. In its pre-cure stage, PDMS consists of multiple components and after curing, the polymerization reactions are usually not competed. Consequently, there are low molecule weight compounds present in the PDMS replica. Environmentally dependent surface changes as well as surface contamination for many polymers are well known. All these lead to changes in surface properties. In this study, the surface properties of PDMS were studied. We have detected the presence of volatile oligosiloxanes in the interface between a PDMS replica and a glass substrate. Also, their behavior at room and elevated temperatures, in particular the adhesion strength between the PDMS-glass interface, was analyzed.

Paper Details

Date Published: 21 June 2002
PDF: 5 pages
Proc. SPIE 4626, Biomedical Nanotechnology Architectures and Applications, (21 June 2002); doi: 10.1117/12.472066
Show Author Affiliations
Boris G. Belenkii, Institute for Analytical Instrumentation (Russia)
Oleg F. Pozdnyakov, A.F. Ioffe Physico-Technical Institute (Russia)
Anatolii A. Evstrapov, Institute for Analytical Instrumentation (Russia)
Victor V. Filimonov, A.F. Ioffe Physico-Technical Institute (Russia)
Vladimir E. Kurochkin, Institute for Analytical Instrumentation (Russia)
Boris P. Redkov, A.F. Ioffe Physico-Technical Institute (Russia)
Vladislav L. Sukhanov, A.F. Ioffe Physico-Technical Institute (Russia)
Zinaida V. Nesterova, Corning Scientific Ctr. (Russia)

Published in SPIE Proceedings Vol. 4626:
Biomedical Nanotechnology Architectures and Applications
Raymond P. Mariella; Catherine J. Murphy; Michelle Palmer; David A. Dunn; Darryl J. Bornhop; David A. Dunn; Raymond P. Mariella; Catherine J. Murphy; Dan V. Nicolau; Shuming Nie; Michelle Palmer; Ramesh Raghavachari; Darryl J. Bornhop; Ramesh Raghavachari; Shuming Nie; Ramesh Raghavachari, Editor(s)

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