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Proceedings Paper

Perturbative theory of the electro-optic response of second-harmonic generation membrane potential sensors
Author(s): Jerome Mertz; Laurent Moreaux; T. Pons
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Paper Abstract

Second-harmonic generation microscopy is a promising tool for the visualization of biological membrane potentials with push-pull chromophores. We describe a response mechanism based on the electric field modulation of chromophore first hyperpolarizabilities. Our model approximates the chromophores as two level systems that incur charge shifts upon optical excitation.

Paper Details

Date Published: 17 June 2002
PDF: 9 pages
Proc. SPIE 4620, Multiphoton Microscopy in the Biomedical Sciences II, (17 June 2002); doi: 10.1117/12.470691
Show Author Affiliations
Jerome Mertz, Ecole Superieure de Physique et de Chimie Industrielles (France)
Laurent Moreaux, Ecole Superieure de Physique et de Chimie Industrielles (France)
T. Pons, Ecole Superieure de Physique et de Chimie Industrielles (France)


Published in SPIE Proceedings Vol. 4620:
Multiphoton Microscopy in the Biomedical Sciences II
Ammasi Periasamy; Peter T. C. So, Editor(s)

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