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Proceedings Paper

Pulsed liquid microjet for intravascular injection
Author(s): Daniel V. Palanker; Daniel A. Fletcher; Jason Miller; Philip Huie; Michael Marmor; Mark Scott Blumenkranz
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Paper Abstract

Occlusions of the retinal veins and arteries are associated with common diseases such as hypertension and arteriosclerosis and usually cause severe and irreversible loss of vision. Treatments for these vascular diseases have been unsatisfactory to date in part because of the difficulty of delivering thrombolytic drugs locally within the eye. In this article we describe a pulsed liquid microjet for minimally invasive intra-vascular drug delivery. The microjet is driven by a vapor bubble following an explosive evaporation of saline, produced by a microsecond-long electric discharge in front of the 25 micrometers electrode inside the micronozzle. Expansion of the transient vapor bubble produces a water jet with a diameter equal to the diameter of the nozzle, and with a velocity and duration that are controlled by the pulse energy. We found that fluid could be injected through the wall of a 60-micrometers -diameter artery in choriallantoic membrane using a 15-micrometers diameter liquid jet traveling at more than 60 m/s. Histological analysis of these arteries showed that the width of the perforation is limited to the diameter of the micronozzle, and the penetration depth of the jet is controlled by the discharge energy. The pulsed liquid microjet offers a promising technique for precise and needle-free intravascular delivery of thrombolytic drugs for localized treatment of retinal vascular occlusions.

Paper Details

Date Published: 13 June 2002
PDF: 4 pages
Proc. SPIE 4611, Ophthalmic Technologies XII, (13 June 2002); doi: 10.1117/12.470608
Show Author Affiliations
Daniel V. Palanker, Stanford Univ. School of Medicine and Stanford Univ. (United States)
Daniel A. Fletcher, Stanford Univ. (United States)
Jason Miller, Stanford Univ. School of Medicine (United States)
Philip Huie, Stanford Univ. School of Medicine and Stanford Univ. (United States)
Michael Marmor, Stanford Univ. School of Medicine (United States)
Mark Scott Blumenkranz, Stanford Univ. School of Medicine (United States)

Published in SPIE Proceedings Vol. 4611:
Ophthalmic Technologies XII
Fabrice Manns; Per G. Soederberg; Arthur Ho, Editor(s)

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