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Proceedings Paper

Optical coherence tomography technique for noninvasive blood glucose monitoring: phantom, animal, and human studies
Author(s): Kirill V. Larin; Taras V. Ashitkov; Irina V. Larina; Irina Y. Petrova; Mohsen S. Eledrisi; Massoud Motamedi; Rinat O. Esenaliev
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Paper Abstract

Continuous noninvasive monitoring of blood glucose concentration can improve management of Diabetes Mellitus, reduce mortality, and considerably improve quality of life of diabetic patients. Recently, we proposed to use the OCT technique for noninvasive glucose monitoring. In this paper, we tested noninvasive blood glucose monitoring with the OCT technique in phantoms, animals, and human subjects. An OCT system with the wavelength of 1300 nm was used in our experiments. Phantom studies performed on aqueous suspensions of polystyrene microspheres and milk showed 3.2% decrease of exponential slope of OCT signals when glucose concentration increased from 0 to 100 mM. Theoretical calculations based on the Mie theory of scattering support the results obtained in phantoms. Bolus glucose injections and glucose clamping experiments were performed in animals (New Zealand rabbits and Yucatan micropigs). Good correlation between changes in the OCT signal slope and actual blood glucose concentration were observed in these experiments. First studies were performed in healthy human subjects (using oral glucose tolerance tests). Dependence of the slope of the OCT signals on the actual blood glucose concentration was similar to that obtained in animal studies. Our studies suggest that the OCT technique can potentially be used for noninvasive blood glucose monitoring.

Paper Details

Date Published: 14 June 2002
PDF: 8 pages
Proc. SPIE 4619, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI, (14 June 2002); doi: 10.1117/12.470478
Show Author Affiliations
Kirill V. Larin, Univ. of Texas Medical Branch at Galveston (United States)
Taras V. Ashitkov, Univ. of Texas Medical Branch at Galveston (United States)
Irina V. Larina, Univ. of Texas Medical Branch at Galveston (United States)
Irina Y. Petrova, Univ. of Texas Medical Branch at Galveston (United States)
Mohsen S. Eledrisi, Univ. of Texas Medical Branch at Galveston (United States)
Massoud Motamedi, Univ. of Texas Medical Branch at Galveston (United States)
Rinat O. Esenaliev, Univ. of Texas Medical Branch at Galveston (United States)


Published in SPIE Proceedings Vol. 4619:
Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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