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Proceedings Paper

Functional imaging of cat primary visual cortex with optical coherence tomography
Author(s): Uma Maheswari Rajagopalan; Hideyuki Takaoka; Ryota Homma; Hirofumi Kadono; Manabu Tanifuji
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Paper Abstract

We report the application of Optical coherence tomography (OCT) for visualizing a one dimensional depth resolved functional structure of cat brain in vivo. The OCT system is based on the known fact that neural activation induces structural changes such as capillary dilation and cellular swelling. Detecting these changes as an amplitude change of the scattered light, an OCT signal reflecting neural activity i.e., fOCT (functional OCT) could be obtained. Experiments have been done to obtain a depth resolved stimulus-specific profile of activation in cat visual cortex. Our results in one dimension indicate that indeed an orientation dependent functional signal could be obtained. Further, we show that this depth resolved fOCT signal is well correlated with the stimulus dependent column determined by OISI. Based on the results, the smallest functional unit in depth, resolved by the proposed system is around 40 micrometers . We are extending our system to perform two dimensional functional imaging.

Paper Details

Date Published: 14 June 2002
PDF: 9 pages
Proc. SPIE 4619, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI, (14 June 2002); doi: 10.1117/12.470474
Show Author Affiliations
Uma Maheswari Rajagopalan, RIKEN---The Institute of Physical and Chemical Research (Japan)
Hideyuki Takaoka, Olympus Optical Co. Ltd. (Japan)
Ryota Homma, RIKEN---The Institute of Physical and Chemical Research (Japan)
Hirofumi Kadono, Saitama Univ. (Japan)
Manabu Tanifuji, RIKEN---The Institute of Physical and Chemical Research (Japan)


Published in SPIE Proceedings Vol. 4619:
Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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