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Proceedings Paper

Optoacoustic imaging of blood for visualization and diagnostics of breast cancer
Author(s): Alexander A. Oraevsky; Elena V. Savateeva; Sergey V. Solomatin; Alexander A. Karabutov; Valeri G. Andreev; Zoran Gatalica; Tuenchit Khamapirad; P. Mark Henrichs
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Paper Abstract

Aggressive malignant tumors may be diagnosed based on relative concentration of oxyhemoglobin and deoxyhemoglobin in the tumor microvasculature. Optoacoustic images of breast cancer and prostate cancer may be acquired at two laser wavelengths matching maximum of oxyhemoglobin (1064-nm, Nd:YAG laser) and deoxyhemoglobin (760-nm, Alexandrite laser). Two optoacoustic systems operating in forward and backward mode respectively for breast cancer and prostate cancer detection, employing arrays of ultravide-band piezoelectric transducers and multichannel electronics was described. After systems testing and calibration in phantoms, initial experiments were performed on patients with suspicious tumors. Quantitative analysis of two-color optoacoustic images was correlated with biopsy and histology. Possibility for tumor differentiation was demonstrated.

Paper Details

Date Published: 10 June 2002
PDF: 14 pages
Proc. SPIE 4618, Biomedical Optoacoustics III, (10 June 2002); doi: 10.1117/12.469851
Show Author Affiliations
Alexander A. Oraevsky, Univ. of Texas Medical Branch at Galveston (United States)
Elena V. Savateeva, Univ. of Texas Medical Branch at Galveston (United States)
Sergey V. Solomatin, Univ. of Texas Medical Branch at Galveston (United States)
Alexander A. Karabutov, Univ. of Texas Medical Branch at Galveston (United States)
Valeri G. Andreev, Univ. of Texas Mecical Branch at Galveston (Russia)
Zoran Gatalica, Univ. of Texas Medical Branch at Galveston (United States)
Tuenchit Khamapirad, Univ. of Texas Medical Branch at Galveston (United States)
P. Mark Henrichs, LaserSonix Technologies, Inc. (United States)


Published in SPIE Proceedings Vol. 4618:
Biomedical Optoacoustics III
Alexander A. Oraevsky, Editor(s)

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