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Proceedings Paper

Application of acoustical thermometry to noninvasive monitoring of internal temperature during laser hyperthermia
Author(s): Eugene V. Krotov; Ivan V. Yakovlev; Maxim Zhadobov; Alexander M. Reyman; Vladimir P. Zharov
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Paper Abstract

This work present the results of experimental study of applicability of acoustical brightness thermometry (ABT) in monitoring of internal temperature during laser hyperthermia and interstitial therapy. In these experiments the radiation of pulse repetition Nd:YAG laser (1064 nm) and continuous diode laser (800 nm) were used as heating sources. Experiments were performed in vitro by insertion of optical fiber inside the objects - optically transparent gelatin with incorporated light absorbing heterogeneities and samples of biological tissues (e.g. liver). During laser heating, internal temperature in absorbing heterogeneity and at fiber end were monitored by means of multi-channel ABT. The independent temperature control was performed with tiny electronic thermometer incorporated in heated zones. The results of experiments demonstrated reasonable sensitivity and accuracy of ABT for real-time temperature control during different kind of laser thermal therapies. According to preliminary data, ABT allow to measure temperature in depth up to 3-5 cm (depends on tissue properties) with spatial resolution some mm. Obtained data show that ABT is a very promising tool to give quantitative measure for different types of energy deposition (laser, microwave, focused ultrasound etc) at the depth commonly encountered in tumors of vital organs. Besides, ABT could give information about diffusion effects in heated zones or optical absorption. This work was supported by Russian Foundation for Basic Research and 6th competition-expertise of young scientists of Russian Academy of Sciences.

Paper Details

Date Published: 10 June 2002
PDF: 8 pages
Proc. SPIE 4618, Biomedical Optoacoustics III, (10 June 2002); doi: 10.1117/12.469846
Show Author Affiliations
Eugene V. Krotov, Institute of Applied Physics (Russia)
Ivan V. Yakovlev, Institute of Applied Physics (Russia)
Maxim Zhadobov, Institute of Applied Physics (Russia)
Alexander M. Reyman, Institute of Applied Physics (Russia)
Vladimir P. Zharov, Univ. of Arkansas for Medical Sciences (United States)


Published in SPIE Proceedings Vol. 4618:
Biomedical Optoacoustics III
Alexander A. Oraevsky, Editor(s)

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