Share Email Print

Proceedings Paper

Retinal macular pigment distribution measured by imaging fundus reflectometry
Author(s): Yin Chang; Sheng-Fu Chen; Feng-Lih Lee; Shih-Jen Chen
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

The existence of macular pigment (MP) in human eyes has been found to be of importance in the prevention of age-related macular degeneration (ARMD). A non-invasive technique of two-wavelength (460 nm and 560 nm) imaging fundus reflectometry was developed to measure the density distribution of this yellow pigment in retina in vivo. A total of 54 healthy human subjects were recruited and divided into three groups, which had average ages and sample sizes of 24.8+/- 2.6 (N=24), 40.2+/- 8.3 (N=13) and 67.5+/- 7.1 years (N=17) respectively. The MP distributions only in the horizontal meridian, which are fitted by Gaussian equation are presented in this report. The results show that the average peak MP densities are 0.48+/- 0.17, 0.46+/- 0.21 and 0.52+/- 0.13 in density unit (DU) from young to old groups respectively. No significant difference is shown in the statistical t-test between the groups of the MP density. The half MP distribution width (covers 95% of Gaussian area) are 5.4 degree(s)+/- 1.6 degree(s), 5.7 degree(s)+/- 2.3 degree(s) and 7.9+/- +/- 2.1 degree(s) from young to old groups respectively. It shows that the area of MP is increased approximately by a rate of 0.06 degree(s)/year. However, the cause of the MP extension in the retina with respect to age is unknown.

Paper Details

Date Published: 4 June 2002
PDF: 9 pages
Proc. SPIE 4625, Clinical Diagnostic Systems: Technologies and Instrumentation, (4 June 2002); doi: 10.1117/12.469786
Show Author Affiliations
Yin Chang, National Yang-Ming Univ. (Taiwan)
Sheng-Fu Chen, National Yang-Ming Univ. (Taiwan)
Feng-Lih Lee, Veterans General Hospital (Taiwan)
Shih-Jen Chen, Veterans General Hospital (Taiwan)

Published in SPIE Proceedings Vol. 4625:
Clinical Diagnostic Systems: Technologies and Instrumentation
Gerald E. Cohn, Editor(s)

© SPIE. Terms of Use
Back to Top