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Proceedings Paper

Development of a hydroxyl radical nanoprobe
Author(s): Matthew King; Raoul Kopelman
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Paper Abstract

A hydroxyl radical nanoprobe has been developed by covalently attaching the dye, coumarin-3-carboxylic acid (CCA), to amine-functionalized polyacrylic acid (AFPAA) nanoparticles. These nanoparticles are referred to as PEBBLEs (Probes Encapsulated By Biologically Localized Embedding). This probe has been shown to be highly specific and sensitive. The formation of hydroxyl radical is monitored by an increase in fluorescence over time.

Paper Details

Date Published: 4 June 2002
PDF: 4 pages
Proc. SPIE 4625, Clinical Diagnostic Systems: Technologies and Instrumentation, (4 June 2002); doi: 10.1117/12.469776
Show Author Affiliations
Matthew King, Univ. of Michigan (United States)
Raoul Kopelman, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 4625:
Clinical Diagnostic Systems: Technologies and Instrumentation
Gerald E. Cohn, Editor(s)

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