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Proceedings Paper

Clinical trials of a new chlorin photosensitizer for photodynamic therapy of malignant tumors
Author(s): Valeriy A. Privalov; Alexander V. Lappa; Oleg V. Seliverstov; Alexey B. Faizrakhmanov; Nicolay N. Yarovoy; Elena V. Kochneva; Michail V. Evnevich; Alla S. Anikina; Andrey V. Reshetnicov; Igor Dmitrievich Zalevsky; Yuriy V. Kemov
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Paper Abstract

Photodynamic therapy (PDT) was performed with a new photosensitizer, a water soluble form of chlorins (Radachlorin, Russia) possessing an absorption peak around 662 nm. As light source there was used the diode laser (ML-662-SP, Russia) with 662 nm wavelength and 2.5 W optical power. The sensitizer had passed broad pre-clinical in vitro and in vivo studies, which showed safety and efficiency of it. PDT was applied to 51 patients with basal cell cancer of the skin (about 60% of all cases), breast cancer, lip cancer, melanoma, cancer of esophagus, stomach, and rectum, cancer and leucoplacia of vulva, malignant ganglioneuroma, sarcoma of soft tissue, cancer and reticular sarcoma of thyroid gland, cancer of ductus choledochus. Most of non-basalioma patients had either forth stage or recurrence of disease. The sensitizer was injected intravenously or applied externally (Radachlorin gel). There were used surface, endoscopic, and interstitial ways of irradiation. Full tumor regression with excellent cosmetic effect was reached in 100% cases of 1-3 stage basal cell cancer patients treated with intravenous Radachlorin injection. In most other (non-basalioma) cases significant regression of tumors and improvement of life quality of patients (recanalization and regain of conductivity) was obtained.

Paper Details

Date Published: 6 June 2002
PDF: 12 pages
Proc. SPIE 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI, (6 June 2002); doi: 10.1117/12.469355
Show Author Affiliations
Valeriy A. Privalov, Chelyabinsk State Medical Academy and Chelyabinsk State Institute of Laser Surgery (Russia)
Alexander V. Lappa, Chelyabinsk State Univ. and Chelyabinsk State Institute of Laser Surgery (Russia)
Oleg V. Seliverstov, Chelyabinsk State Medical Academy (Russia)
Alexey B. Faizrakhmanov, Chelyabinsk State Medical Academy (Russia)
Nicolay N. Yarovoy, Chelyabinsk State Medical Academy (Russia)
Elena V. Kochneva, Chelyabinsk State Medical Academy (Russia)
Michail V. Evnevich, Chelyabinsk State Univ. (Russia)
Alla S. Anikina, Chelyabinsk State Univ. and Chelyabinsk State Institute of Laser Surgery (Russia)
Andrey V. Reshetnicov, Rada-Pharma Co., Ltd. (Russia)
Igor Dmitrievich Zalevsky, Sigma Plus Co., Ltd. (Russia)
Yuriy V. Kemov, Rada-Pharma Co., Ltd. (Russia)


Published in SPIE Proceedings Vol. 4612:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI
Thomas J. Dougherty, Editor(s)

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