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Proceedings Paper

Tumor detection with sonodynamic chemiluminescence from ATX-70 and FCLA under ultrasonic excitation
Author(s): Yonghong He; Da Xing; Yong Yao; Guihong Yan; Ken-ichi Ueda
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Paper Abstract

A new tumor detection method by use of sonodynamic chemiluminescence was proposed in our previous work. In this paper, we further improved the diagnosis sensitivity by use of Gallium-porphyrin analogue ATX-70, one of the most active sonosensitizer found. In vitro experiments, sono-chemiluminescence of ATX-70 + FCLA system is about two times stronger than that of HpD + FCLA system. The sono-chemiluminescence was inhibited by 1O2 scavenger, but was not affected by other free radical scavenger. The mechanism of sonosensitizing was discussed. In vivo experiments, a more clearly tumor diagnostic image was obtained.

Paper Details

Date Published: 6 June 2002
PDF: 8 pages
Proc. SPIE 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI, (6 June 2002); doi: 10.1117/12.469348
Show Author Affiliations
Yonghong He, South China Normal Univ. (China)
Da Xing, South China Normal Univ. (China)
Yong Yao, South China Normal Univ. (China)
Guihong Yan, South China Normal Univ. (China)
Ken-ichi Ueda, Univ. of Electro-Communications (Japan)


Published in SPIE Proceedings Vol. 4612:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI
Thomas J. Dougherty, Editor(s)

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