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Proceedings Paper

Ultrasound backscatter microscopy/spectroscopy and optical coherence (Doppler) tomography for mechanism-specific monitoring of photodynamic therapy in vivo and in vitro
Author(s): Victor X.D. Yang; Greg J. Gzarnota; I. Alex Vitkin; Mike C. Kolios; Michael D. Sherar; Johannes F. de Boer; Bruce J. Tromberg; Brian C. Wilson
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Paper Abstract

Photodynamic therapy (PDT) can induce a variety of tissue changes, including apoptosis, oncosis, and vascular responses. A preliminary study using two non-invasive imaging techniques, ultrasound backscatter microscopy/spectroscopy (UBM/UBS) and optical coherence/Doppler tomography (OCT/ODT), is presented. Photofrin PDT of melanoma was studied using a mouse model and imaged by both modalities in vivo. Post PDT, increase in the signal intensity and change in the backscatter spectrum were observed in UBM/UBS. A transient increase in the signal attenuation was observed by OCT and changes in the neovasculular blood flow were detected using ODT. Additional in vitro experiments were performed to examine the possible causes of the observed signal changes.

Paper Details

Date Published: 6 June 2002
PDF: 8 pages
Proc. SPIE 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI, (6 June 2002); doi: 10.1117/12.469342
Show Author Affiliations
Victor X.D. Yang, Univ. of Toronto and Ontario Cancer Institute/Princess Margaret Hospital (Canada)
Greg J. Gzarnota, Univ. of Toronto and Ontario Cancer Institute/Princess Margaret Hospital (Canada)
I. Alex Vitkin, Univ. of Toronto and Ontario Cancer Institute/Princess Margaret Hospital (Canada)
Mike C. Kolios, Univ. of Toronto and Ontario Cancer Institute/Princess Margaret Hospital (Canada)
Michael D. Sherar, Univ. of Toronto and Ontario Cancer Institute/Princess Margaret Hospital (Canada)
Johannes F. de Boer, Beckman Laser Institute and Medical Clinic (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (United States)
Brian C. Wilson, Univ. of Toronto and Ontario Cancer Institute/Princess Margaret Hospital (Canada)


Published in SPIE Proceedings Vol. 4612:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI
Thomas J. Dougherty, Editor(s)

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