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Proceedings Paper

ALA-containing transparent applicators on the basis of biodegradable polymers for photodynamic therapy of superficial malignancies
Author(s): Gennadii A. Meerovich; Victor B. Loschenov; Victor V. Shental; Elena G. Vakoulovskaya; Anatoly B. Davydov; Gennady L. Khromov; Sergei G. Kuzmin; Eugeny A. Lukyanets; Iosif I. Tkach; Georgy N. Vorozhtsov
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Paper Abstract

The efficiency of photodynamic therapy (PDT) using 5- aminolevulinic acid (5-ALA) is essentially determined by an optimal choice of sensitization means, among which the application method is one of the most perspective due to high permeability of a skin for 5-ALA. The aim of present work is optimization of sensitization process with ALA. We have used the possibility of 5-ALA transparency in applicator (outside of tissue) while protoporphyrin-IX, formed in sensitized tissue, has sufficient absorption for providing PDT. We have developed 5-ALA containing applicator on the basis of transparent biodegradable polymers, which serve as a programmed source of 5-ALA in the zone of their contact with pathological tissue. The investigations carried out on mice with the solid form of leucosis p-388, have shown that developed applicator provides effective sensitization of pathological tissue, supporting high concentration of photosensitizer in tissue during the whole time of application (up to week). The experiments in vivo have demonstrated high efficiency of PDT. The preliminary clinical researches allow to draw a conclusion about its perspectivity for photodynamic treatment of skin malignancies.

Paper Details

Date Published: 6 June 2002
PDF: 8 pages
Proc. SPIE 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI, (6 June 2002); doi: 10.1117/12.469338
Show Author Affiliations
Gennadii A. Meerovich, General Physics Institute (Russia)
Victor B. Loschenov, General Physics Institute (Russia)
Victor V. Shental, Cancer Research Ctr./Academy of Medical Sciences (Russia)
Elena G. Vakoulovskaya, Cancer Research Ctr./Academy of Medical Sciences (Russia)
Anatoly B. Davydov, State Scientfic Ctr. NIOPIK (Russia)
Gennady L. Khromov, State Scientfic Ctr. NIOPIK (Russia)
Sergei G. Kuzmin, State Scientfic Ctr. NIOPIK (Russia)
Eugeny A. Lukyanets, State Scientfic Ctr. NIOPIK (Russia)
Iosif I. Tkach, State Scientfic Ctr. NIOPIK (Russia)
Georgy N. Vorozhtsov, State Scientfic Ctr. NIOPIK (Russia)

Published in SPIE Proceedings Vol. 4612:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI
Thomas J. Dougherty, Editor(s)

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