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Proceedings Paper

Multisensory fiber optic probes for PDT dosimetry: construction, performance, and error analysis
Author(s): Natalie Pomerleau; Lothar D. Lilge
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Paper Abstract

Photodynamic therapy (PDT) is gradually gaining widespread acceptance as an alternative or adjunct therapy to standard oncologic treatment modalities. Effective PDT treatment is dependent on the interaction of the photosensitizer, treatment light, and molecular oxygen. Much room for improvement exists in the area of PDT dosimetry, especially for deep-seated tumors. To this end, multi-sensory fiber optic probes that detect the fluence rate have been developed. Selected fluorophores are placed in grooves at multiple (1-5) positions along a 250micrometers optical fiber. PLS-based deconvolution of the detected fluorescence emission spectrum yields the fluorescence intensity, and hence the fluence rate, at each sensor location. Single- fluorophore probes were used to elucidate properties of individual sensors. Results with these single-sensor probes, performance with PLS-based algorithm, and preliminary performance of multi-sensor probes will be presented.

Paper Details

Date Published: 6 June 2002
PDF: 9 pages
Proc. SPIE 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI, (6 June 2002); doi: 10.1117/12.469334
Show Author Affiliations
Natalie Pomerleau, Univ. of Toronto (Canada)
Lothar D. Lilge, Photonics Research Ontario (Canada)


Published in SPIE Proceedings Vol. 4612:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI
Thomas J. Dougherty, Editor(s)

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