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Proceedings Paper

Time-dependent spectra of PPIX after ALA and h-ALA application
Author(s): Dirk Huettenberger; Hans-Jochen Foth; Volker Zenzen; Heinrich Zankl
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Paper Abstract

The transition of the tumor fluorescence from auto fluorescence towards PpIX fluorescence was studied under spectral and spatial resolution in an in-vivo tumour model. Human tumour cells were embedded on the chorioallantois membrane (CAM) of fertilised hen's eggs. A time period of 8 days is sufficient to grow tumours of a size of several millimeters. After the application of ALA and h-ALA the intensity and the wavelength spectra of the fluorescence were observed under blue light exposure (lambda) = 405 nm) by the spectrometer SpectraCube. 1-2 hours after the application of the photosensitizer the spectra show the yield of the typical double peak structure of PpIX.

Paper Details

Date Published: 6 June 2002
PDF: 7 pages
Proc. SPIE 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI, (6 June 2002); doi: 10.1117/12.469333
Show Author Affiliations
Dirk Huettenberger, Univ. of Kaiserslautern (Germany)
Hans-Jochen Foth, Univ. of Kaiserslautern (Germany)
Volker Zenzen, Univ. of Kaiserslautern (Germany)
Heinrich Zankl, Univ. of Kaiserslautern (Germany)


Published in SPIE Proceedings Vol. 4612:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI
Thomas J. Dougherty, Editor(s)

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