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Proceedings Paper

Pulmonary drug delivery using droplets generated by Rayleigh instability-driven breakup of filaments
Author(s): Yen-Peng Kong; Yuan Xu; Francis E. H. Tay
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Paper Abstract

For effective pulmonary drug delivery of insulin for example, drug particles must be in the range of 1 to 5 microns. A piezoelectrically actuated MEMS atomizer based on Rayleigh instability-driven breakup of filaments has been designed to produce drug particles in this range. Although the formation of droplets from jets have been used extensively in ink-jet printing, the currently presented mode of droplet formation has not yet been demonstrated by any MEMS device. Testing of the vaporiser reveals that the droplets generated lie primarily in the range of 1.0 through 3.0 microns, a range that covers the designed droplet size of 2.5 microns. We thus show that it is possible to implement this mode of droplet generation that will achieve better device efficiency.

Paper Details

Date Published: 14 November 2002
PDF: 10 pages
Proc. SPIE 4937, Biomedical Applications of Micro- and Nanoengineering, (14 November 2002); doi: 10.1117/12.469086
Show Author Affiliations
Yen-Peng Kong, Institute of Materials Research and Engineering (Singapore)
Yuan Xu, Institute of Materials Research and Engineering (Singapore)
Francis E. H. Tay, National Univ. of Singapore (Singapore)


Published in SPIE Proceedings Vol. 4937:
Biomedical Applications of Micro- and Nanoengineering
Dan V. Nicolau, Editor(s)

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