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Proceedings Paper

Kinetic description of dioxygen binding to human hemoglobin on the 1-100 ns time scale
Author(s): I. V. Sazanovich; Vladimir A. Galievsky; J. Karpiuk; E. P. Petrov; Jacek Waluk; Boris M. Dzhagarov
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Paper Abstract

The results of nanosecond optical spectroscopy studies of hemoglobin geminate recombination on the 1-100 ns time scale are presented. Analysis of transient absorption data has shown that (i) the kinetics of O2 recombination to hemoglobin cannot be described as a single-exponential process, and (ii) the predominant part of geminate recombination takes place on the initial stage of this process. The analysis pattern as two exponentials and background yields two processes occurring during the geminate recombination on the 1-100 ns time scale having the time constants of 1.2 +/- 0.2 ns and 16 +/- 2 ns. However, the signal-to-noise ratio of the data does not allow to make an unambiguous between several possible non-exponential decay models.

Paper Details

Date Published: 30 May 2002
PDF: 5 pages
Proc. SPIE 4749, ICONO 2001: Novel Trends in Nonlinear Laser Spectroscopy and Optical Diagnostics and Lasers in Chemistry, Biophysics, and Biomedicine, (30 May 2002); doi: 10.1117/12.468915
Show Author Affiliations
I. V. Sazanovich, Institute of Molecular and Atomic Physics (Belarus)
Vladimir A. Galievsky, Institute of Molecular and Atomic Physics (Belarus)
J. Karpiuk, Institute of Physical Chemistry (Poland)
E. P. Petrov, B.I. Stepanov Institute of Physics (Belarus)
Jacek Waluk, Institute of Physical Chemistry (Poland)
Boris M. Dzhagarov, Institute of Molecular and Atomic Physics (Belarus)


Published in SPIE Proceedings Vol. 4749:
ICONO 2001: Novel Trends in Nonlinear Laser Spectroscopy and Optical Diagnostics and Lasers in Chemistry, Biophysics, and Biomedicine

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