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Proceedings Paper

Photodynamic laser therapy in the transparency region of biotissues using tricarbocyanine dyes as photosensitizers
Author(s): Eugene S. Voropay; Michael Petrovitch Samtsov; Anatoliy P. Lugovsky; Vadim N. Chalov; Elena N. Alexandrova; Edvard A. Zhavrid; Yury P. Istomin
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Paper Abstract

Investigation of the spectral properties of polymethine dyes in organic solvents, water, nutritious media and cell cultures at various concentrations has demonstrated that the tumor cells contain monomers of the dye molecules. Pharmacokinetics of the different dyes has been studied both in vivo and in vitro. After incubation of a cell culture in the presence of a nontoxic does of the dyes their concentration in tumor cells is rather high, varying for different preparations from 10-11 2.1 10-9 mol per million cells. The biggest phototoxicity in vitro has been observed for polymethine dyes with indolenine end groups. In vivo concentration of the dyes in tumor tissues was higher than in normal muscle tissues ranging from 1.2 to 3.6 for different kinds of tumor. Photo bleaching of dyes during photodynamic treatment was observed. The photodynamic treatment with some polymethine dyes caused tumor tissue necrosis up to 20 mm in depth.

Paper Details

Date Published: 30 May 2002
PDF: 7 pages
Proc. SPIE 4749, ICONO 2001: Novel Trends in Nonlinear Laser Spectroscopy and Optical Diagnostics and Lasers in Chemistry, Biophysics, and Biomedicine, (30 May 2002); doi: 10.1117/12.468896
Show Author Affiliations
Eugene S. Voropay, A.N. Sevchenko Research Institute for Applied Physical Problems (Belarus)
Michael Petrovitch Samtsov, A.N. Sevchenko Research Institute for Applied Physical Problems (Belarus)
Anatoliy P. Lugovsky, A.N. Sevchenko Research Institute for Applied Physical Problems (Belarus)
Vadim N. Chalov, N.N. Alexandrov Scientific Research Institute of Oncology and Medical Radiology (Belarus)
Elena N. Alexandrova, Research Institute of Oncology and Medical Radiology (Belarus)
Edvard A. Zhavrid, N.N. Alexandrov Scientific Research Institute of Oncology and Medical Radiology (Belarus)
Yury P. Istomin, N.N. Alexandrov Scientific Research Institute of Oncology and Medical Radiology (Belarus)


Published in SPIE Proceedings Vol. 4749:
ICONO 2001: Novel Trends in Nonlinear Laser Spectroscopy and Optical Diagnostics and Lasers in Chemistry, Biophysics, and Biomedicine

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