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Proceedings Paper

Influence of tissue movements on laser Doppler perfusion imaging
Author(s): Daniel M.G. Karlsson; Marcus Larsson; Tomas Stroemberg; Karin Wardell
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Paper Abstract

The microvascular perfusion can be measured using laser Doppler blood flowmetry (LDF), a technique sensitive to the concentration of moving blood cells and their velocity. However, movements of the tissue itself can cause artifacts in the perfusion readings. In a clinical situation, these movement induced artifacts may arise from patient movements or from movements of internal organs e.g. the intestines or the beating heart. Therefore, we have studied how a well-controlled tissue movement affects the LDF signals during different flow conditions and for different surface structures. Tissue perfusion was recorded non-touch in one point using a laser Doppler perfusion imager. During the measurements the object was placed on a shaker that generated the movement (both horizontal and vertical). Measurements were carried out both on DELRIN (polyacetal plastic) and the fingertip, for a wide range of velocities (0-3 cm/s). The influence of the microvascular perfusion was evaluated by occluding the brachial artery as well as blood emptying the finger and by using a flow model. The LDF signals were correlated to the movement. In vivo measurements showed that velocities above 0.8 cm/s gave a significant contribution to the perfusion signal. Corresponding velocities for the DELRIN piece were higher (1.4 - 2.6 cm/s), and dependent on the surface structures and reflecting properties. By reducing the amount of specular reflection the movement influence was substantially lowered.

Paper Details

Date Published: 23 May 2002
PDF: 9 pages
Proc. SPIE 4624, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, (23 May 2002); doi: 10.1117/12.468313
Show Author Affiliations
Daniel M.G. Karlsson, Linkoepings Univ. (Sweden)
Marcus Larsson, Linkoepings Univ. (Sweden)
Tomas Stroemberg, Linkoepings Univ. (Sweden)
Karin Wardell, Linkoepings Univ. (Sweden)

Published in SPIE Proceedings Vol. 4624:
Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II
Alexander V. Priezzhev; Gerard L. Cote, Editor(s)

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