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Proceedings Paper

Online measurement of urea concentration in spent dialysate during hemodialysis
Author(s): Jonathon T. Olesberg; Ben Armitage; Mark A. Arnold; Michael Flanigan
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Paper Abstract

We describe on-line optical measurements of urea concentration during the regular hemodialysis treatment of several patients. The spectral measurements were performed in the effluent dialysate stream after the dialysis membrane using an FTIR spectrometer equipped with a flow-through cell. Spectra were recorded across the 5000-4000 cm-1 (2.0-2.5 micrometers at 1-minute intervals. Optically determined concentrations matched concentrations obtained from standard chemical assays with a root-mean-square error of 0.29 mM for urea (0.8 mg/dl urea nitrogen), 0.03 mM for creatinine, 0.11 mM for lactate, and 0.22 mM for glucose. The observed concentration ranges were 0-11 mM for urea, 0-0.35 mM for creatinine, 0-0.75 mM for lactate, and 9-12.5 mM for glucose.

Paper Details

Date Published: 23 May 2002
PDF: 11 pages
Proc. SPIE 4624, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, (23 May 2002); doi: 10.1117/12.468312
Show Author Affiliations
Jonathon T. Olesberg, Univ. of Iowa (United States)
Ben Armitage, Univ. of Iowa (United States)
Mark A. Arnold, Univ. of Iowa (United States)
Michael Flanigan, College of Medicine/Univ. of Iowa (United States)


Published in SPIE Proceedings Vol. 4624:
Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II
Alexander V. Priezzhev; Gerard L. Cote, Editor(s)

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