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Proceedings Paper

Quantitative MR assessment of longitudinal parenchymal changes in children treated for medulloblastoma
Author(s): Wilburn E. Reddick; John O. Glass; Shingjie Wu; Shawna L. Palmer; Raymond K. Mulhern; Amar Gajjar
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Paper Abstract

Our research builds on the hypothesis that white matter damage, in children treated for cancer with cranial spinal irradiation, spans a continuum of severity that can be reliably probed using non-invasive MR technology and results in potentially debilitating neurological and neuropsychological problems. This longitudinal project focuses on 341 quantitative volumetric MR examinations from 58 children treated for medulloblastoma (MB) with cranial irradiation (CRT) of 35-40 Gy. Quadratic mixed effects models were used to fit changes in tissue volumes (white matter, gray matter, CSF, and cerebral) with time since CRT and age at CRT as covariates. We successfully defined algorithms that are useful in the prediction of brain development among children treated for MB.

Paper Details

Date Published: 9 May 2002
PDF: 9 pages
Proc. SPIE 4684, Medical Imaging 2002: Image Processing, (9 May 2002); doi: 10.1117/12.467208
Show Author Affiliations
Wilburn E. Reddick, St. Jude Children's Research Hospital (United States)
John O. Glass, St. Jude Children's Research Hospital (United States)
Shingjie Wu, St. Jude Children's Research Hospital (United States)
Shawna L. Palmer, St. Jude Children's Research Hospital (United States)
Raymond K. Mulhern, St. Jude Children's Research Hospital (United States)
Amar Gajjar, St. Jude Children's Research Hospital (United States)


Published in SPIE Proceedings Vol. 4684:
Medical Imaging 2002: Image Processing
Milan Sonka; J. Michael Fitzpatrick, Editor(s)

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